Briefly describe the key steps involved in the synthesis and degradation of filaggrin during terminal differentiation of the epidermis
NO PLAGIARISM AT australianwritingacademy.com/
1. Answer all parts of this question:
a) Briefly describe the key steps involved in the synthesis and degradation of
filaggrin during terminal differentiation of the epidermis (3 marks). Define the
structure and function of filaggrin (2 marks).
b) Briefly describe the key steps involved in the synthesis and degradation of
ceramides in the epidermis. A diagram may be used. (5 marks)
c) List the major functions of ceramides and briefly discuss the evidence for
ceramide abnormalities in canine atopic dermatitis. (5 marks)
2. Answer all parts of this question:
a) Briefly describe the four (4) mechanisms involved in the transfer of melanin to
keratinocytes. (8 marks)
b) Define the abnormality of melanisation associated with Chediak–Higashi
syndrome. (2 marks)
c) Complete the table provided in the answer booklet for the intrinsic factors that
influence hair growth. (5 marks)
3. Answer all parts of this question:
a) List the molecular components (including associated ligands) of anchoring
filaments of the normal basement membrane. (6 marks)
b) Name one (1) acquired disease of anchoring filaments and the associated
molecular target. (2 marks)
c) Briefly describe the outcome of interleukin 17 A (IL-17 A) activation of canine
keratinocytes (2 marks) and the potential role of IL-17 A in the development of
canine atopic dermatitis (5 marks).
Section B continued over page
Veterinary Dermatology Paper 1 Page 6 of 8
© 2016 The Australian and New Zealand College of Veterinary Scientists ABN 00 50 000894 208
4. Answer all parts of this question:
a) Briefly describe the development of immunological tolerance to ingested
antigens in the normal dog. (5 marks)
b) List factors that may reduce antigen exclusion to ingested antigens promoting a
loss of oral tolerance. (5 marks)
c) Discuss mechanisms that could explain why hypersensitivity to an ingested
antigen may induce cutaneous rather than gastrointestinal disease. (5 marks)
PLACE THIS ORDER OR A SIMILAR ORDER WITH LITE ESSAYS TODAY AND GET AN AMAZING DISCOUNT
The post Briefly describe the key steps involved in the synthesis and degradation of filaggrin during terminal differentiation of the epidermis appeared first on .
WE WRITE QUALITY PAPERS FOR A+ RESULTS. NO PLAGIARISM..!!
The post Briefly describe the key steps involved in the synthesis and degradation of filaggrin during terminal differentiation of the epidermis appeared first on AUSTRALIAN ACADEMICS.
Looking for a Similar Assignment? Order now and Get 10% Discount! Use Coupon Code "Newclient"
