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Attention Deficit Disorder Essay.

Attention Deficit Disorder Essay.

 

Attention Deficit Disorder (ADD) Approximately 3-5% of all American children have an Attention Deficit Disorder (ADD). ADD is a leading cause of school failure and under-achievement. ADD characteristics often arise in early childhood. As many as 50% of children with ADD are never diagnosed. Boys significantly outnumber girls, though girls are more likely to be undiagnosed with ADD. “ADD is not an attention disorder, but a disorder of impulse control ( Seminar notes Barkeley) .” Characteristics of Attention Deficit Disorder can include : Fidgeting with hands or feet, difficulty remaining seated, awaiting turns in games, following through on instructions , shifting from one uncompleted task to another, difficulty playing quietly, interrupting conversations and intruding into other children’s games, appearing to be not listening to what is being said, doing things that are dangerous without thinking about the consequences. Most scientist now believe that a brain dysfunction or abnormality in brain chemistry could be to blame for the symptoms of Attention Deficit Disorder. The frontal lobes of the brain are thought to be most responsible for the regulation of behavior and attention.Attention Deficit Disorder Essay.

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They receive information from the lower brain, which regulated arousal and screens incoming messages from within and outside of the body. The limbic system , a group of related nervous system structures located in the midbrain and linked to emotions and feelings, also sends messages to the frontal lobes. Finally, the frontal lobes are suspected to be the site of working memory, the place where information about the immediate environment is considered for memory storage, planning, and future-directed behavior. Scientist believe the activity in the frontal lobes is depressed in people with ADD. Studies show a decrease in the ability of the ADD brain to use glucose, the body’s main source of energy, leading to slower and less efficient activity. Neurotransmitters provide the connection between one nerve cell and another. In essence, neurotransmitters allow electrical impulses to pass across synapses from one neuron to another. It is now suspected that people with Attention Deficit Disorder have a chemical imbalance of a class of neurotransmitters called catecholamines. Dopamine, helps to form a pathway between the motor center of the midbrain and the frontal lobes, as well as a pathway between the limbic system and the frontal lobes. Without enough dopamine and related catecholamines, such as serotonin and norepinephrine, the frontal lobes are under stimulated and thus unable to perform their complex functions efficiently. Attention Deficit Disorder is strongly considered genetically inherited, however, not all cases of ADD may be genetically linked. . Studies have shown that 20-30% of all hyperactive children have a least one parent with ADD. The environment is a big influence on a child during pregnancy and after. Some studies show that a small percentage of ADD cases were influenced by smoking, drinking alcohol, and using drugs during pregnancy. Exposure to toxins, such as lead, may also alter the brain chemistry and function. If you suspect that you are suffering from Attention Deficit Disorder you will need to discuss it with your medical doctor. In most cases the doctor will recommend that you visit a psychologist for an evaluation. The psychologist is professionally trained in human behavior and will be able to provide counseling and testing in areas related to mental health. The psychologist is not able to prescribe medication to help you, but may send you to a psychiatrist to prescribe and monitor medication. A neurologist may be consulted in order to rule out neurological conditions causing your symptoms. Your doctor will gather information about your past and present difficulties, medical history , current psychological makeup, educational and behavioral functioning. Depending on your symptoms, your diagnosis may be categorized as ADD, inattentive type ADD, or hyperactive/impulsive type ADD. After your diagnosis you may learn that you are also suffering from a learning disability, depression, or substance abuse, which is often associated with ADD. There is no cure for Attention Deficit Disorder. “Along with increasing awareness of the problem, a better understanding of its causes and treatment has developed (3 Wender)”. There is medication for ADD which will only alleviate the symptoms. The medication will not permanently restore the chemical balance. Attention Deficit Disorder Essay.Approximately 70% of adults with ADD find that their symptoms significantly improve after they take medication prescribed by their doctors. The patient is able to concentrate on difficult and time-consuming tasks, stop impulsive behavior , and tame the restless twitches that have been experienced in the past. Some ADD patient’s psychological and behavioral problems are not solved by medication alone, and are required more therapy or training . There are two types of drugs that work to balance the neurotransmitters and have been found to be most effective in treating ADD. Stimulants are drugs that stimulate or activate brain activity. Stimulants work by increasing the amount of dopamine either produced in the brain or used by the frontal lobes of the brain. There are several different stimulants that may work to alleviate the symptoms of ADD, including methylphenidate (Ritalin), dextroamphetamine (Dexedrine), and pemoline (Cylert). Stimulants are by far the most effective medications in the treatment of ADD. Some patients respond well to antidepressants. Antidepressants also stimulate brain activity in the frontal lobes, but they affect the production and use of other chemicals, usually norepinephrine and serotonin. The antidepressants considered most useful for ADD include imipramine (Tofranil), desipramine (Norpramin), bupropion ( Wellbutrin), and fluoxetine hydrochloride (Prozac). All stimulants have the same set of side effects. Some patients complain of feeling nauseous or headachy at the outset of treatment, but find that these side effects pass within a few days. Others find that their appetites are suppressed and or that they have difficulty sleeping. If the stimulant dosage is too high the patient may experience feelings of nervousness, agitation, and anxiety, In rare cases, increased heart rate and high blood pressure can result with the use of stimulants, especially if the patient has an underlying predisposition toward hypertension. Ritalin is the most widely prescribed drug used to treat ADD in both children and adults. Ritalin appears to work by stimulating the production of the neurotransmitter dopamine. The benefits of Ritalin include improved concentration and reduced distractibility and disorganization. Dextroamphetamine is another stimulant medication that appears to have a slightly different pharmacological action than Ritalin. Both work to boost the amount of available dopamine. Dextroamphetamine, however, blocks the reuptake of the neurotransmitter while Ritalin increases its production (334 Kelly, Ramundo, Press). All the drugs used to treat ADD have the same goal: to provide the brain with the raw materials it needs to concentrate over a sustained period of time, control impulses, and regulate motor activity. The drug or combination of drugs that work best for you depends on the individuals brain chemistry and constellation of symptoms. The process of finding the right drug can be tricky for each individual. The physicians are not able to accurately predict how any one individual will respond to various doses or types of Attention Deficit Disorder medication. Medication is rarely enough for the patient. Most Attention Deficit Disorder patients require therapy to give guidance . Adult patients have the burden of the past that often hinders their progress. The patient then needs help with the relief of disappointment, frustration, and nagging sense of self-doubt that often weighs upon the ADD patient. Some ADD patients suffer from low-grade depression or anxiety, others with a dependence on alcohol or drugs, and most with low self-esteem and feelings of helplessness. Therapy also helps the ADD patient fully understand the disorder and how it controls the patients life. The knowledge of ADD will make the patient and parents more capable of changing the behaviors or circumstances disliked and enhancing strengths and assets. A second and most crucial part of the education process involves informing those around you about the disorder and its effects. Family members, friends, employers, and colleagues have been playing roles in the drama called ADD without ever being aware of it. Explaining how the disorder may affect the relationships around the patient will help repair any past damage as well as pave the way to a stable future. Attention Deficit Disorder is difficult for any family. ADD challenges the relationships and the issues of daily family life.Attention Deficit Disorder Essay. Getting a family household to function smoothly is challenging for any family, with or without the presence of ADD. Adults and children suffering from Attention Deficit Disorder have trouble establishing and maintaining physical order, coordinating schedules and activities, and accepting and meeting responsibilities. Parents with children
suffering with ADD have to learn how to deal with the obstacles that they will have while raising their child. Adults dealing with ADD often have chronic employment problems, impulsive spending, and erratic bookkeeping and bill paying. Raising healthy, well-adjusted children requires patience, sound judgment, good humor, and, discipline which is difficult for an ADD parent to do. The presence of ADD often hinders the development of intimate relationships for a variety of reasons. Although many adults with ADD enjoy successful, satisfying marriages, the disorder almost always adds a certain amount of extra tension and pressure to the union. The non-ADD spouse bears an additional burden of responsibility for keeping the household running smoothly and meeting the needs of the children, the spouse with ADD, and, if he or she has time, his or her own priorities. Parenting a child who has ADD can be an exhausting and, at times, frustrating experience. Parents play a key role in managing the disability. Attention Deficit Disorder Essay.

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American Health & Fitness Essay.

American Health & Fitness Essay.

 

AIDS and YOU Introduction: AIDS is a life and death issue. To have the AIDS disease is at present a sentence of slow but inevitable death. I’ve already lost one friend to AIDS. I may soon lose others. My own sexual behavior and that of many of my friends has been profoundly altered by it. In my part of the country, one man in 10 may already be carrying the AIDS virus. While the figures may currently be less in much of the rest of the country, this is changing rapidly. There currently is neither a cure, nor even an effective treatment, and no vaccine either. But there are things that have been PROVEN immensely effective in slowing the spread of this hideously lethal disease. In this essay I hope to present this information.American Health & Fitness Essay.

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History and Overview: AIDS stands for Acquired Immune Defficiency Disease. It is caused by a virus. The disease originated somewhere in Africa about 20 years ago. There it first appeared as a mysterious ailment afflicting primarily heterosexuals of both sexes. It probably was spread especially fast by primarily female prostitutes there. AIDS has already become a crisis of STAGGERING proportions in parts of Africa. In Zaire, it is estimated that over twenty percent of the adults currently carry the virus. That figure is increasing. And what occurred there will, if no cure is found, most likely occur here among heterosexual folks. AIDS was first seen as a disease of gay males in this country. This was a result of the fact that gay males in this culture in the days before AIDS had an average of 200 to 400 new sexual contacts per year. This figure was much higher than common practice among heterosexual (straight) men or women.American Health & Fitness Essay.

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In addition, it turned out that rectal sex was a particularly effective way to transmit the disease, and rectal sex is a common practice among gay males. For these reasons, the disease spread in the gay male population of this country immensely more quickly than in other populations. It became to be thought of as a “gay disease”. Because the disease is spread primarily by exposure of ones blood to infected blood or semen, I.V. drug addicts who shared needles also soon were identified as an affected group. As the AIDS epidemic began to affect increasingly large fractions of those two populations (gay males and IV drug abusers), many of the rest of this society looked on smugly, for both populations tended to be despised by the “mainstream” of society here. But AIDS is also spread by heterosexual sex. In addition, it is spread by blood transfusions.American Health & Fitness Essay.

New born babies can acquire the disease from infected mothers during pregnancy. Gradually more and more “mainstream” folks got the disease. Most recently, a member of congress died of the disease. Finally, even the national news media began to join in the task of educating the public to the notion that AIDS can affect everyone. Basic medical research began to provide a few bits of information, and some help.

The virus causing the disease was isolated and identified. The AIDS virus turned out to be a very unusual sort of virus. Its genetic material was not DNA, but RNA. When it infected human cells, it had its RNA direct the synthesis of viral DNA. While RNA viruses are not that uncommon, very few RNA viruses reproduce by setting up the flow of information from RNA to DNA. Such reverse or “retro” flow of information does not occur at all in any DNA virus or any other living things. Hence, the virus was said to belong to the rar group of virues called “Retro Viruses”. Research provided the means to test donated blood for the presence of the antibodies to the virus, astronomically reducing the chance of ones getting AIDS from a blood transfusion. This was one of the first real breakthroughs. The same discoveries that allowed us to make our blood bank blood supply far safer also allowed us to be able to tell (in most cases) whether one has been exposed to the AIDS virus using a simple blood test.

The Types of AIDS Infection: When the AIDS virus gets into a person’s body, the results can be broken down into three general types of situations: AIDS disease, ARC, and asymptomatic seropositive condition. The AIDS disease is characterized by having one’s immune system devastated by the AIDS virus. One is said to have the *disease* if one contracts particular varieties (Pneumocystis, for example) of pneumonia, or one of several particular varieties of otherwise rare cancers (Kaposi’s Sarcoma, for example). This *disease* is inevitably fatal. Death occurs often after many weeks or months of expensive and painful hospital care. Most folks with the disease can transmit it to others by sexual contact or other exposure of an uninfected person’s blood to the blood or semen of the infected person. There is also a condition referred to as ARC (“Aids Related Complex”). In this situation, one is infected with the AIDS virus and one’s immune system is compromised, but not so much so that one gets the (ultimately lethal) cancers or pneumonias of the AIDS disease.

One tends to be plagued by frequent colds, enlarged lymph nodes, and the like. This condition can go on for years. One is likely to be able to infect others if one has ARC. Unfortunately, all those with ARC are currently felt to eventually progess to getting the full blown AIDS disease. There are, however, many folks who have NO obvious signs of disease what so ever, but when their blood serum is tested they show positive evidence of having been exposed to the virus. This is on the basis of the fact that antibodies to the AIDS virus are found in their blood. Such “asymptomatic but seropositive” folks may or may not carry enough virus to be infectious. Most sadly, though, current research and experience with the disease would seem to indicate that EVENTUALLY, nearly all folks who are seropostive will develop the full blown AIDS disease. There is one ray of hope here: It may in some cases take up to 15 years or more between one’s becoming seropositive for the AIDS virus and one’s developing the disease. Thus, all those millions (soon to be tens and hundreds of millions) who are now seropositive for AIDS are under a sentence of death, but a sentence that may not be carried out for one or two decades in a significan fraction of cases. Medical research holds the possibility of commuting that sentence, or reversing it.American Health & Fitness Essay.

There is one other fact that needs to be mentioned here because it is highly significant in determining recommendations for safe sexual conduct which will be discussed below: Currently, it is felt that after exposure to the virus, most folks will turn seropositive for it (develop a positive blood test for it) within four months. It is currently felt that if you are sexually exposed to a person with AIDS and do not become seropositive within six months after that exposure, you will never become seropositive as a result of that exposure. Just to confuse the issue a little, there are a few folks whose blood shows NO antibodies to the virus, but from whom live virus has been cultured. Thus, if one is serongative, it is not absolute proof one is not exposed to the virus. This category of folks is very hard to test for, and currently felt to be quite rare. Some even speculate that such folks may be rare examples of those who are immune to the effects of the virus, but this remains speculation. It is not known if such folks can also transmit the virus. Transmission of AIDS: The AIDS virus is extremely fragile, and is killed by exposure to mild detergents or to chlorox, among other things. AIDS itself may be transmitted by actual virus particles, or by the transmission of living human cells that contain AIDS viral DNA already grafted onto the human DNA. Or both. Which of these two mechanisms is the main one is not known as I write this essay. But the fact remains that it is VERY hard to catch AIDS unless one engages in certain specific activities. What will NOT transmit AIDS? Casual contact (shaking hands, hugging, sharing tools) cannot transmit AIDS. Although live virus has been recovered from saliva of AIDS patients, the techniques used to do this involved concentrating the virus to extents many thousands of times greater than occurs in normal human contact, such as kissing (including “deep” or “French” kissing). Thus, there remains no solid evidence that even “deep” kissing can transmit AIDS. Similarly, there is no evidence that sharing food or eating utensils with an AIDS patient can transmit the virus.American Health & Fitness Essay.

The same is true for transmission by sneezing or coughing. There just is no current evidence that the disease can be transmitted that way.The same may be true even for BITING,though here there may be some increased (though still remote) chance of transmitting the disease. The above is very important. It means that there is NO medical reason WHAT SO EVER to recommend tha AIDS suffers or AIDS antibody positive folks be quarrantined. Such recommendations are motivated either by ignorance or by sinister desires to set up concentration camps. Combined with the fact that the disease is already well established in this country, the above also means that there is no rational medical basis for immigration laws preventing visits by AIDS suffers or antibody positive persons. The above also means that friends and family and coworkers of AIDS patients and seropostive persons have nothing to fear from such casual contact. There is no reason to not show your love or concern for a friend with AIDS by embracing the person. Indeed, there appears still to be NO rational basis for excluding AIDS suffers from food preparation activity. Even if an AIDS suffer cuts his or her finger and bleeds into the salad or soup, most of the cells and virus will die, in most cases, before the food is consumed. In addition, it is extremely difficult to get successfully attacked by AIDS via stuff you eat. AIDS cannot be transmitted by the act of GIVING blood to a blood bank. All equipment used for such blood donation is sterile, and is used just once, and then discarded. How is AIDS transmitted? Sexual activity is one of the primary ways AIDS is transmitted. AIDS is transmitted particulary by the transmission of blood or semen of an infected person into contact with the blood of an uninfected person. Sex involving penetration of the penis into either the vagina of a woman or the rectum of either a woman or a man has a very high risk of transmitting the disease. It is felt to be about four times MORE likely for an infected male to transmit AIDS to an uninfected woman in the course of vaginal sex than it is likely for an infected woman to transmit AID to an uninfected male. This probably relates to the greater area of moist tissue in a woman’s vagina, and to the relative liklihood of microscopic tears to occur in that tissue during sex. But the bottom line is that AIDS can be transmitted in EITHER direction in the case of heterosexual sex. Transmission among lesbians (homosexual females) is rare. Oral sex is an extremely common form of sexual activity among both gay and straight folks. Such activity involves contact of infected semen or vaginal secretions with the mouth, esophagus (the tube that connects the mouth with the stomach) and the stomach. AIDS virus and infected cells most certainly cannot survive the acid environment of the stomach. Yet, it is still felt that there is a chance of catching the disease by having oral sex with an infected person. The chance is probably a lot smaller than in the case of vaginal or rectal sex, but is still felt to be significant. As mentioned above, AIDS is also transmitted among intravenous drug users by the sharing of needles. Self righteous attitudes by the political “leaders” of this country at local, state, and national levels have repeatedly prevented the very rational approach of providing free access to sterile intravenous equipment for IV drug users. This measure, when taken promptly in Amsterdam, was proven to greatly and SIGNIFICANTLY slow the spread of the virus in that population. The best that rational medical workers have succeeded in doing here in San Francisco is distribute educational leaflets and cartoons to the I.V. drug abusing population instructing them in the necessity of their rinsing their “works” with chlorox before reusing the same needle in another person. Note that even if you don’t care what happens to I.V. drug abusers, the increase in the nuber of folks carrying the virus ultimately endangers ALL living persons. Thus, the issue is NOT what you morally think of I.V. drug addicts, but one of what is the most rational way to slow the spread of AIDS in all populations. Testing of donated blood for AIDS has massivly reduced the chance of catching AIDS from blood transfusions. But a very small risk still remains. To further reduce that risk, efforts have been made to use “autotransfusions” in cases of “elective surgery” (surgery that can be planned months in advance). Autotransfusion involves the patient storing their own blood a couple of weeks prior to their own surgery, to be used during the surgery if needed. Similary, setting up donations of blood from friends and family known to be antibody negative and at low risk for AIDS prior to schedualed surgery further can decrease the already small risks from transfusion. AIDS and SEX: What are the rational options? The “sexual revolution” of the 1960’s has been stopped dead in its tracks by the AIDS epidemic. The danger of contracting AIDS is so real now that it has massively affected the behavior of both gay and straight folks who formerly had elected to lead an active sexual life that included numerous new sexual contacts. Abstinence The safest option regarding AIDS and sex is total abstinence from all sexual contact. For those who prefer to indulge in sexual contact, this is often far too great a sacrifice. But it IS an option to be considered. Safe Sex For those who wish to have sexual contact with folks on a relatively casual basis, there have been devised rules for “safe sex”. These rules are very strict, and will be found quite objectionable by most of us who have previously enjoyed unrestricted sex. But to violate these rules is to risk unusually horrible death. Once one gets used to them, tho, the rule for “safe sex” do allow for quite acceptable sexual enjoyment in most cases. For those who wish to indulge in pentration of the vagina or rectum by a penis: The penis MUST be sheathed in a condom or “rubber”. This must be done “religiously”, and NO exceptions are allowed. A condom must be used by a man even when he is receiving oral sex. Cunnilingus (oral stimulation of a womans gentitals by the mouth of a lover) is NOT considerd to be safe sex. Safe sex includes mutual masturbation, and the stimultion of one genitals by another’s hand (provided there are no cuts in the skin on that hand). But manual stimulation of another’s genitals is NOT safe if one has cuts on one’s hands, unless one is wearing a glove. American Health & Fitness Essay.

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American Health & Fitness Essay.

American Health & Fitness Essay.

 

AIDS and YOU Introduction: AIDS is a life and death issue. To have the AIDS disease is at present a sentence of slow but inevitable death. I’ve already lost one friend to AIDS. I may soon lose others. My own sexual behavior and that of many of my friends has been profoundly altered by it. In my part of the country, one man in 10 may already be carrying the AIDS virus. While the figures may currently be less in much of the rest of the country, this is changing rapidly. There currently is neither a cure, nor even an effective treatment, and no vaccine either. But there are things that have been PROVEN immensely effective in slowing the spread of this hideously lethal disease. In this essay I hope to present this information.American Health & Fitness Essay.

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History and Overview: AIDS stands for Acquired Immune Defficiency Disease. It is caused by a virus. The disease originated somewhere in Africa about 20 years ago. There it first appeared as a mysterious ailment afflicting primarily heterosexuals of both sexes. It probably was spread especially fast by primarily female prostitutes there. AIDS has already become a crisis of STAGGERING proportions in parts of Africa. In Zaire, it is estimated that over twenty percent of the adults currently carry the virus. That figure is increasing. And what occurred there will, if no cure is found, most likely occur here among heterosexual folks. AIDS was first seen as a disease of gay males in this country. This was a result of the fact that gay males in this culture in the days before AIDS had an average of 200 to 400 new sexual contacts per year. This figure was much higher than common practice among heterosexual (straight) men or women.American Health & Fitness Essay.

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In addition, it turned out that rectal sex was a particularly effective way to transmit the disease, and rectal sex is a common practice among gay males. For these reasons, the disease spread in the gay male population of this country immensely more quickly than in other populations. It became to be thought of as a “gay disease”. Because the disease is spread primarily by exposure of ones blood to infected blood or semen, I.V. drug addicts who shared needles also soon were identified as an affected group. As the AIDS epidemic began to affect increasingly large fractions of those two populations (gay males and IV drug abusers), many of the rest of this society looked on smugly, for both populations tended to be despised by the “mainstream” of society here. But AIDS is also spread by heterosexual sex. In addition, it is spread by blood transfusions.American Health & Fitness Essay.

New born babies can acquire the disease from infected mothers during pregnancy. Gradually more and more “mainstream” folks got the disease. Most recently, a member of congress died of the disease. Finally, even the national news media began to join in the task of educating the public to the notion that AIDS can affect everyone. Basic medical research began to provide a few bits of information, and some help.

The virus causing the disease was isolated and identified. The AIDS virus turned out to be a very unusual sort of virus. Its genetic material was not DNA, but RNA. When it infected human cells, it had its RNA direct the synthesis of viral DNA. While RNA viruses are not that uncommon, very few RNA viruses reproduce by setting up the flow of information from RNA to DNA. Such reverse or “retro” flow of information does not occur at all in any DNA virus or any other living things. Hence, the virus was said to belong to the rar group of virues called “Retro Viruses”. Research provided the means to test donated blood for the presence of the antibodies to the virus, astronomically reducing the chance of ones getting AIDS from a blood transfusion. This was one of the first real breakthroughs. The same discoveries that allowed us to make our blood bank blood supply far safer also allowed us to be able to tell (in most cases) whether one has been exposed to the AIDS virus using a simple blood test.

The Types of AIDS Infection: When the AIDS virus gets into a person’s body, the results can be broken down into three general types of situations: AIDS disease, ARC, and asymptomatic seropositive condition. The AIDS disease is characterized by having one’s immune system devastated by the AIDS virus. One is said to have the *disease* if one contracts particular varieties (Pneumocystis, for example) of pneumonia, or one of several particular varieties of otherwise rare cancers (Kaposi’s Sarcoma, for example). This *disease* is inevitably fatal. Death occurs often after many weeks or months of expensive and painful hospital care. Most folks with the disease can transmit it to others by sexual contact or other exposure of an uninfected person’s blood to the blood or semen of the infected person. There is also a condition referred to as ARC (“Aids Related Complex”). In this situation, one is infected with the AIDS virus and one’s immune system is compromised, but not so much so that one gets the (ultimately lethal) cancers or pneumonias of the AIDS disease.

One tends to be plagued by frequent colds, enlarged lymph nodes, and the like. This condition can go on for years. One is likely to be able to infect others if one has ARC. Unfortunately, all those with ARC are currently felt to eventually progess to getting the full blown AIDS disease. There are, however, many folks who have NO obvious signs of disease what so ever, but when their blood serum is tested they show positive evidence of having been exposed to the virus. This is on the basis of the fact that antibodies to the AIDS virus are found in their blood. Such “asymptomatic but seropositive” folks may or may not carry enough virus to be infectious. Most sadly, though, current research and experience with the disease would seem to indicate that EVENTUALLY, nearly all folks who are seropostive will develop the full blown AIDS disease. There is one ray of hope here: It may in some cases take up to 15 years or more between one’s becoming seropositive for the AIDS virus and one’s developing the disease. Thus, all those millions (soon to be tens and hundreds of millions) who are now seropositive for AIDS are under a sentence of death, but a sentence that may not be carried out for one or two decades in a significan fraction of cases. Medical research holds the possibility of commuting that sentence, or reversing it.American Health & Fitness Essay.

There is one other fact that needs to be mentioned here because it is highly significant in determining recommendations for safe sexual conduct which will be discussed below: Currently, it is felt that after exposure to the virus, most folks will turn seropositive for it (develop a positive blood test for it) within four months. It is currently felt that if you are sexually exposed to a person with AIDS and do not become seropositive within six months after that exposure, you will never become seropositive as a result of that exposure. Just to confuse the issue a little, there are a few folks whose blood shows NO antibodies to the virus, but from whom live virus has been cultured. Thus, if one is serongative, it is not absolute proof one is not exposed to the virus. This category of folks is very hard to test for, and currently felt to be quite rare. Some even speculate that such folks may be rare examples of those who are immune to the effects of the virus, but this remains speculation. It is not known if such folks can also transmit the virus. Transmission of AIDS: The AIDS virus is extremely fragile, and is killed by exposure to mild detergents or to chlorox, among other things. AIDS itself may be transmitted by actual virus particles, or by the transmission of living human cells that contain AIDS viral DNA already grafted onto the human DNA. Or both. Which of these two mechanisms is the main one is not known as I write this essay. But the fact remains that it is VERY hard to catch AIDS unless one engages in certain specific activities. What will NOT transmit AIDS? Casual contact (shaking hands, hugging, sharing tools) cannot transmit AIDS. Although live virus has been recovered from saliva of AIDS patients, the techniques used to do this involved concentrating the virus to extents many thousands of times greater than occurs in normal human contact, such as kissing (including “deep” or “French” kissing). Thus, there remains no solid evidence that even “deep” kissing can transmit AIDS. Similarly, there is no evidence that sharing food or eating utensils with an AIDS patient can transmit the virus.American Health & Fitness Essay.

The same is true for transmission by sneezing or coughing. There just is no current evidence that the disease can be transmitted that way.The same may be true even for BITING,though here there may be some increased (though still remote) chance of transmitting the disease. The above is very important. It means that there is NO medical reason WHAT SO EVER to recommend tha AIDS suffers or AIDS antibody positive folks be quarrantined. Such recommendations are motivated either by ignorance or by sinister desires to set up concentration camps. Combined with the fact that the disease is already well established in this country, the above also means that there is no rational medical basis for immigration laws preventing visits by AIDS suffers or antibody positive persons. The above also means that friends and family and coworkers of AIDS patients and seropostive persons have nothing to fear from such casual contact. There is no reason to not show your love or concern for a friend with AIDS by embracing the person. Indeed, there appears still to be NO rational basis for excluding AIDS suffers from food preparation activity. Even if an AIDS suffer cuts his or her finger and bleeds into the salad or soup, most of the cells and virus will die, in most cases, before the food is consumed. In addition, it is extremely difficult to get successfully attacked by AIDS via stuff you eat. AIDS cannot be transmitted by the act of GIVING blood to a blood bank. All equipment used for such blood donation is sterile, and is used just once, and then discarded. How is AIDS transmitted? Sexual activity is one of the primary ways AIDS is transmitted. AIDS is transmitted particulary by the transmission of blood or semen of an infected person into contact with the blood of an uninfected person. Sex involving penetration of the penis into either the vagina of a woman or the rectum of either a woman or a man has a very high risk of transmitting the disease. It is felt to be about four times MORE likely for an infected male to transmit AIDS to an uninfected woman in the course of vaginal sex than it is likely for an infected woman to transmit AID to an uninfected male. This probably relates to the greater area of moist tissue in a woman’s vagina, and to the relative liklihood of microscopic tears to occur in that tissue during sex. But the bottom line is that AIDS can be transmitted in EITHER direction in the case of heterosexual sex. Transmission among lesbians (homosexual females) is rare. Oral sex is an extremely common form of sexual activity among both gay and straight folks. Such activity involves contact of infected semen or vaginal secretions with the mouth, esophagus (the tube that connects the mouth with the stomach) and the stomach. AIDS virus and infected cells most certainly cannot survive the acid environment of the stomach. Yet, it is still felt that there is a chance of catching the disease by having oral sex with an infected person. The chance is probably a lot smaller than in the case of vaginal or rectal sex, but is still felt to be significant. As mentioned above, AIDS is also transmitted among intravenous drug users by the sharing of needles. Self righteous attitudes by the political “leaders” of this country at local, state, and national levels have repeatedly prevented the very rational approach of providing free access to sterile intravenous equipment for IV drug users. This measure, when taken promptly in Amsterdam, was proven to greatly and SIGNIFICANTLY slow the spread of the virus in that population. The best that rational medical workers have succeeded in doing here in San Francisco is distribute educational leaflets and cartoons to the I.V. drug abusing population instructing them in the necessity of their rinsing their “works” with chlorox before reusing the same needle in another person. Note that even if you don’t care what happens to I.V. drug abusers, the increase in the nuber of folks carrying the virus ultimately endangers ALL living persons. Thus, the issue is NOT what you morally think of I.V. drug addicts, but one of what is the most rational way to slow the spread of AIDS in all populations. Testing of donated blood for AIDS has massivly reduced the chance of catching AIDS from blood transfusions. But a very small risk still remains. To further reduce that risk, efforts have been made to use “autotransfusions” in cases of “elective surgery” (surgery that can be planned months in advance). Autotransfusion involves the patient storing their own blood a couple of weeks prior to their own surgery, to be used during the surgery if needed. Similary, setting up donations of blood from friends and family known to be antibody negative and at low risk for AIDS prior to schedualed surgery further can decrease the already small risks from transfusion. AIDS and SEX: What are the rational options? The “sexual revolution” of the 1960’s has been stopped dead in its tracks by the AIDS epidemic. The danger of contracting AIDS is so real now that it has massively affected the behavior of both gay and straight folks who formerly had elected to lead an active sexual life that included numerous new sexual contacts. Abstinence The safest option regarding AIDS and sex is total abstinence from all sexual contact. For those who prefer to indulge in sexual contact, this is often far too great a sacrifice. But it IS an option to be considered. Safe Sex For those who wish to have sexual contact with folks on a relatively casual basis, there have been devised rules for “safe sex”. These rules are very strict, and will be found quite objectionable by most of us who have previously enjoyed unrestricted sex. But to violate these rules is to risk unusually horrible death. Once one gets used to them, tho, the rule for “safe sex” do allow for quite acceptable sexual enjoyment in most cases. For those who wish to indulge in pentration of the vagina or rectum by a penis: The penis MUST be sheathed in a condom or “rubber”. This must be done “religiously”, and NO exceptions are allowed. A condom must be used by a man even when he is receiving oral sex. Cunnilingus (oral stimulation of a womans gentitals by the mouth of a lover) is NOT considerd to be safe sex. Safe sex includes mutual masturbation, and the stimultion of one genitals by another’s hand (provided there are no cuts in the skin on that hand). But manual stimulation of another’s genitals is NOT safe if one has cuts on one’s hands, unless one is wearing a glove. American Health & Fitness Essay.

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Clinical Chemistry Tests in Medicine Essay.

Clinical Chemistry Tests in Medicine Essay.

 

A discussion of blood tests used as a diagnostic tool in medicine.

Clinical Chemistry Tests in Medicine Of the diagnostic methods available to veterinarians, the clinical chemistry test has developed into a valuable aid for localizing pathologic conditions. This test is actually a collection of specially selected individual tests. With just a small amount of whole blood or serum, many body systems can be analyzed. Some of the more common screenings give information about the function of the kidneys, liver, and pancreas and about muscle and bone disease. There are many blood chemistry tests available to doctors. This paper covers the some of the more common tests. Blood urea nitrogen (BUN) is an end-product of protein metabolism. Like most of the other molecules in the body, amino acids are constantly renewed. In the course of this turnover, they may undergo deamination, the removal of the amino group. Deamination, which takes place principally in the liver, results in the formation of ammonia. In the liver, the ammonia is quickly converted to urea, which is relatively nontoxic, and is then released into the bloodstream. In the blood, it is readily removed through the kidneys and excreted in the urine. Any disease or condition that reduces glomerular filtration or increases protein catabolism results in elevated BUN levels. Creatinine is another indicator of kidney function.Clinical Chemistry Tests in Medicine Essay.

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Creatinine is a waste product derived from creatine. It is freely filtered by the glomerulus and blood levels are useful for estimating glomerular filtration rate. Muscle tissue contains phosphocreatinine which is converted to creatinine by a nonenzymatic process. This spontaneous degradation occurs at a rather consistent rate (Merck, 1991). Causes of increases of both BUN and creatinine can be divided into three major categories: prerenal, renal, and postrenal. Prerenal causes include heart disease, hypoadrenocorticism and shock. Postrenal causes include urethral obstruction or lacerations of the ureter, bladder, or urethra. True renal disease from glomerular, tubular, or interstitial dysfunction raises BUN and creatinine levels when over 70% of the nephrons become nonfunctional (Sodikoff, 1995). Glucose is a primary energy source for living organisms.

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The glucose level in blood is normally controlled to within narrow limits. Inadequate or excessive amounts of glucose or the inability to metabolize glucose can affect nearly every system in the body. Low blood glucose levels (hypoglycemia) may be caused by pancreatic tumors (over-production of insulin), starvation, hypoadrenocorticism, hypopituitarism, and severe exertion. Elevated blood glucose levels (hyperglycemia) can occur in diabetes mellitus, hyperthyroidism, hyperadrenocorticism, hyperpituitarism, anoxia (because of the instability of liver glycogen in oxygen deficiency), certain physiologic conditions (exposure to cold, digestion) and pancreatic necrosis (because the pancreas produces insulin which controls blood glucose levels).Clinical Chemistry Tests in Medicine Essay.

Diabetes mellitus is caused by a deficiency in the secretion or action of insulin. During periods of low blood glucose, glucagon stimulates the breakdown of liver glycogen and inhibits glucose breakdown by glycolysis in the liver and stimulates glucose synthesis by gluconeogenesis. This increases blood glucose. When glucose enters the bloodstream from the intestine after a carbohydrate-rich meal, the resulting increase in blood glucose causes increased insulin secretion and decreased glucagon secretion. Insulin stimulates glucose uptake by muscle tissue where glucose is converted to glucose-6-phosphate. Insulin also activates glycogen synthase so that much of the glucose-6-phosphate is converted to glycogen. It also stimulates the storage of excess fuels as fat (Lehninger, 1993). With insufficient insulin, glucose is not used by the tissues and accumulates in the blood. The accumulated glucose then spills into the urine. Additional amounts of water are retained in urine because of the accumulation of glucose and polyuria (excessive urination) results. In order to prevent dehydration, more water than normal is consumed (polydipsia). In the absence of insulin, fatty acids released form adipose tissue are converted to ketone bodies (acetoacetic acid, B-hydroxybutyric acid, and acetone).

Although ketone bodies can be used a energy sources, insulin deficiency impairs the ability of tissues to use ketone bodies, which accumulate in the blood. Because they are acids, ketones may exhaust the ability of the body to maintain normal pH. Ketones are excreted by the kidneys, drawing water with them into the urine. Ketones are also negatively charged and draw positively charged ions (sodium, potassium, calcium) with them into urine. Some other results of diabetes mellitus are cataracts (because of abnormal glucose metabolism in the lens which results in the accumulation of water), abnormal neutrophil function (resulting in greater susceptibility to infection), and an enlarged liver (due to fat accumulation) (Fraser, 1991).Clinical Chemistry Tests in Medicine Essay.

Bilirubin is a bile pigment derived from the breakdown of heme by the reticuloendothelial system. The reticuloendothelial system filters out and destroys spent red blood cells yielding a free iron molecule and ultimately, bilirubin. Bilirubin binds to serum albumin, which restricts it from urinary excretion, and is transported to the liver. In the liver, bilirubin is changed into bilirubin diglucuronide, which is sufficiently water soluble to be secreted with other components of bile into the small intestine. Impaired liver function or blocked bile secretion causes bilirubin to leak into the blood, resulting in a yellowing of the skin and eyeballs (jaundice). Determination of bilirubin concentration in the blood is useful in diagnosing liver disease (Lehninger, 1993). Increased bilirubin can also be caused by hemolysis, bile duct obstruction, fever, and starvation (Bistner, 1995). Two important serum lipids are cholesterol and triglycerides.

Cholesterol is a precursor to bile salts and steroid hormones. The principle bile salts, taurocholic acid and glycocholic acid, are important in the digestion of food and the solubilization of ingested fats. The desmolase reaction converts cholesterol, in mitochondria, to pregnenolone which is transported to the endoplasmic reticulum and converted to progesterone. This is the precursor to all other steroid hormones (Garrett, 1995). Triglycerides are the main form in which lipids are stored and are the predominant type of dietary lipid. They are stored in specialized cells called adipocytes (fat cells) under the skin, in the abdominal cavity, and in the mammary glands. As stored fuels, triglycerides have an advantage over polysaccharides because they are unhydrated and lack the extra water weight of polysaccharides. Also, because the carbon atoms are more reduced than those of sugars, oxidation of triglycerides yields more than twice as much energy, gram for gram, as that of carbohydrates (Lehninger, 1993). Hyperlipidemia refers to an abnormally high concentration of triglyceride and/or cholesterol in the blood. Primary hyperlipidemia is an inherited disorder of lipid metabolism. Secondary hyperlipidemias are usually associated with pancreatitis, diabetes mellitus, hypothyroidism, protein losing glomerulonephropathies, glucocorticosteroid administration, and a variety of liver abnormalities. Read about test for presence of protein in food

Hypolipidemia is almost always a result of malnutrition (Barrie, 1995). Alkaline phosphatase is present in high concentration in bone and liver. Bone remodeling (disease or repair) results in moderate elevations of serum alkaline phosphatase levels, and cholestasis (stagnation of bile flow) and bile duct obstruction result in dramatically increased serum alkaline phosphatase levels. The obstruction is usually intrahepatic, associated with swelling of hepatocytes and bile stasis. Elevated serum alkaline phosphatase and bilirubin levels suggest bile duct obstruction. Elevated serum alkaline phosphatase and normal bilirubin levels suggest hepatic congestion or swelling. Elevations also occur in rapidly growing young animals and in conditions causing bone formation (Bistner, 1995). Aspartate aminotransferase (AST) is an enzyme normally found in the mitochondria of liver, heart, and skeletal muscle cells. In the event of heart or liver damage, AST leaks into the blood stream and concentrations become elevated (Bistner, 1995).

AST, along with alkaline phosphatase, are used to differentiate between liver and muscle damage in birds. Alanine aminotransferase (ALT) is considered a liver-specific enzyme, although small amounts are present in the heart. ALT is generally located in the cytosol. Liver disease results in the releasing of the enzyme into the serum. Measurements of this enzyme are used in the diagnosis of certain types of liver diseases such as viral hepatitis and hepatic necrosis, and heart diseases. The ALT level remains elevated for more than a week after hepatic injury (Sodikoff, 1995). Fibrinogen, albumin, and globulins constitute the major proteins of the blood plasma. Fibrinogen, which makes up about 0.3 percent of the total protein volume, is a soluble protein involved in the clotting process. The formation of blood clots is the result of a series of zymogen activations. Factors released by injured tissues or abnormal surfaces caused by injury initiate the clotting process. To create the clot, thrombin removes negatively charged peptides from fibrinogen, converting it to fibrin. The fibrin monomer has a different surface charge distribution than fibrinogen. These monomers readily aggregates into ordered fibrous arrays. Platelets and plasma globulins release a fibrin-stabilizing factor which creates cross-links in the fibrin net to stabilize the clot. The clot binds the wound until new tissue can be built (Garrett, 1995). The alpha-, beta-, and gamma-globulins compose the globulins. Alpha-globulins transport lipids, hormones, and vitamins. Also included is a glycoprotein, ceruloplasmin, which carries copper and haptoglobulins, which bind hemoglobin. Iron transport is related to beta-globulins. The glycoprotein that binds the iron is transferrin (Lehninger, 1993). Gamma-globulins (immunoglobulins) are associated with antibody formation. There are five different classes of immunoglobulins. IgG is the major circulating antibody. It gives immune protection within the body and is small enough to cross the placenta, giving newborns temporary protection against infection. IgM also gives protection within the body but is too large to cross the placenta. IgA is normally found in mucous membranes, saliva, and milk. It provides external protection. IgD is thought to function during the development and maturation of the immune response. IgE makes of the smallest fraction of the immunoglobulins. It is responsible for allergic and hypersensitivity reactions. Altered levels of alpha- and beta- globulins are rare, but immunoglobulin levels change in various conditions. Serum immunoglobulin levels can increase with viral or bacterial infection, parasitism, lymphosarcoma, and liver disease. Levels are decreased in immunodeficiency. Albumin is a serum protein that affects osmotic pressure, binds many drugs, and transports fatty acids. Albumin is produced in the liver and is the most prevalent serum protein, making up 40 to 60 percent of the total protein. Serum albumin levels are decreased (hypoalbuminemia) by starvation, parasitism, chronic liver disease, and acute glomerulonephritis (Sodikoff, 1995). Albumin is a weak acid and hypoalbuminemia will tend to cause nonrespiratory alkalosis (de Morais, 1995). Serum albumin levels are often elevated in shock or severe dehydration. Creatine Kinase (CK) is an enzyme that is most abundant in skeletal muscle, heart muscle, and nervous tissue. CK splits creatine phosphate in the presence of adenosine diphosphate (ADP) to yield creatine and adenosine triphosphate (ATP). During periods of active muscular contraction and glycolysis, this reaction proceeds predominantly in the direction of ATP synthesis. During recovery from exertion, CK is used to resynthesize creatine phosphate from creatine at the expense of ATP. After a heart attack, CK is the first enzyme to appear in the blood (Lehninger, 1993). CK values become elevated from muscle damage (from trauma), infarction, muscular dystrophies, or inflammation. Elevated CK values can also be seen following intramuscular injections of irritating substances. Muscle diseases may be associated with direct damage to muscle fibers or neurogenic diseases that result in secondary damage to muscle fibers. Greatly increased CK values are usually associated with heart muscle disease because of the large number of mitochondria in heart muscle cells (Bistner, 1995). When active muscle tissue cannot be supplied with sufficient oxygen, it becomes anaerobic and produces pyruvate from glucose by glycolysis. Lactate dehydrogenase (LDH) catalyzes the regeneration of NAD+ from NADH so glycolysis can continue. The lactate produced is released into the blood. Heart tissue is aerobic and uses lactate as a fuel, converting it to pyruvate via LDH and using the pyruvate to fuel the citric acid cycle to obtain energy (Lehninger, 1993). Because of the ubiquitous origins of LDH, the total serum level is not reliable for diagnosis; but in normal serum, there are five isoenzymes of LDH which give more specific information. These isoenzymes can help differentiate between increases in LDH due to liver, muscle, kidney, or heart damage or hemolysis (Bistner, 1995). Calcium is involved in many processes of the body, including neuromuscular excitability, muscle contraction, enzyme activity, hormone release, and blood coagulation. Calcium is also an important ion in that it affects the permeability of the nerve cell membrane to sodium. Without sufficient calcium, muscle spasms can occur due to erratic, spontaneous nervous impulses. The majority of the calcium in the body is found in bone as phosphate and carbonate. In blood, calcium is available in two forms. The nondiffusible form is bound to protein (mainly albumin) and makes up about 45 percent of the measurable calcium. This bound form is inactive. The ionized forms of calcium are biologically active. If the circulating level falls, the bones are used as a source of calcium. Primary control of blood calcium is dependent on parathyroid hormone, calcitonin, and the presence of vitamin D. Parathyroid hormone maintains blood calcium level by increasing its absorption in the intestines from food and reducing its excretion by the kidneys. Parathyroid hormone also stimulates the release of calcium into the blood stream from the bones. Hyperparathyroidism, caused by tumors of the parathyroid, causes the bones to lose too much calcium and become soft and fragile. Calcitonin produces a hypocalcemic effect by inhibiting the effect of parathyroid hormone and preventing calcium from leaving bones. Vitamin D stimulates calcium and phosphate absorption in the small intestine and increases calcium and phosphate utilization from bone. Hypercalcemia may be caused by abnormal calcium/phosphorus ratio, hyperparathyroidism, hypervitaminosis D, and hyperproteinemia. Hypocalcemia may be caused by hypoproteinemia, renal failure, or pancreatitis (Bistner, 1995). Because approximately 98 percent of the total body potassium is found at the intracellular level, potassium is the major intracellular cation. This cation is filtered by the glomeruli in the kidneys and nearly completely reabsorbed by the proximal tubules. It is then excreted by the distal tubules. There is no renal threshold for potassium and it continues to be excreted in the urine even in low potassium states. Therefore, the body has no mechanism to prevent excessive loss of potassium (Schmidt-Nielsen, 1995). Potassium plays a critical role in maintaining the normal cellular and muscular function. Any imbalance of the body’s potassium level, increased or decreased, may result in neuromuscular dysfunction, especially in the heart muscle. Serious, and sometimes fatal, arrythmias may develop. A low serum potassium level, hypokalemia, occurs with major fluid loss in gastrointestinal disorders (i.e., vomiting, diarrhea), renal disease, diuretic therapy, diabetes mellitus, or mineralocorticoid dysfunction (i.e., Cushing’s disease). An increased serum potassium level, hyperkalemia, occurs most often in urinary obstruction, anuria, or acute renal disease (Bistner, 1995). Sodium and its related anions (i.e., chloride and bicar
bonate) are primarily responsible for the osmotic attraction and retention of water in the extracellular fluid compartments. The endothelial membrane is freely permeable to these small electrolytes. Sodium is the most abundant extracellular cation, however, very little is present intracellularly. The main functions of sodium in the body include maintenance of membrane potentials and initiation of action potentials in excitable membranes. The sodium concentration also largely determines the extracellular osmolarity and volume. The differential concentration of sodium is the principal force for the movement of water across cellular membranes. In addition, sodium is involved in the absorption of glucose and some amino acids from the gastrointestinal tract (Lehninger, 1993). Sodium is ingested with food and water, and is lost from the body in urine, feces, and sweat. Most sodium secreted into the GI tract is reabsorbed. The excretion of sodium is regulated by the renin-angiotensin-aldosterone system (Schmidt-Nielsen, 1995). Decreased serum sodium levels, hyponatremia, can be seen in adrenal insufficiency, inadequate sodium intake, renal insufficiency, vomiting or diarrhea, and uncontrolled diabetes mellitus. Hypernatremia may occur in dehydration, water deficit, hyperadrenocorticism, and central nervous system trauma or disease (Bistner, 1995). Chloride is the major extracellular anion. Chloride and bicarbonate ions are important in the maintenance of acid-base balance. When chloride in the form of hydrochloric acid or ammonium chloride is lost, alkalosis follows; when chloride is retained or ingested, acidosis follows. Elevated serum chloride levels, hyperchloremia, can be seen in renal disease, dehydration, overtreatment with saline solution, and carbon dioxide deficit (as occurs from hyperventilation). Decreased serum chloride levels, hypochloremia, can be seen in diarrhea and vomiting, renal disease, overtreatment with certain diuretics, diabetic acidosis, hypoventilation (as occurs in pneumonia or emphysema), and adrenal insufficiency (de Morais, 1995). As seen above, one to two milliliters of blood can give a clinician a great insight to the way an animals’ systems are functioning. With many more tests available and being developed every day, diagnosis becomes less invasive to the patient. The more information that is made available to the doctor allows a faster diagnosis and recovery for the patient. Bibliography Barrie, Joan and Timothy D. G. Watson. “Hyperlipidemia.” Current Veterinary Therapy XII. Ed. John Bonagura. Philadelphia: W. B. Saunders, 1995. Bistner, Stephen l. Kirk and Bistner’s Handbook of Veterinary Procedures and Emergency Treatment. Philadelphia: W. B. Saunders, 1995. de Morais, HSA and William W. Muir. “Strong Ions and Acid-Base Disorders.” Current Veterinary Therapy XII. Ed. John Bonagura. Philadelphia: W. B. Saunders, 1995. Fraser, Clarence M., ed. The Merck Veterinary Manual, Seventh Edition. Rahway, N. J.: Merck & Co., 1991. Garrett, Reginald H. and Charles Grisham. Biochemistry. Fort Worth: Saunders College Publishing, 1995. Lehninger, Albert, David Nelson and Michael Cox. Principles of Biochemistry. New York: Worth Publishers, 1993. Schmidt-Nielsen, Knut. Animal Physiology: Adaptation and environment. New York: Cambridge University Press, 1995. Sodikoff, Charles. Labratory Profiles of Small Animal Diseases. Santa Barbara: American Veterinary Publications, 1995.Clinical Chemistry Tests in Medicine Essay.

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