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What are the key cellular differences between non-Hodgkin lymphoma and Hodgkin lymphoma?

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Max is a 60-year-old living in Iowa. For the 27 years, he has been working in the agricultural industry, particularly in the management of corn production. Recently he began to feel weak during work and tired easily. During the night he woke up sweating, and he often felt unusually warm during the day. Max was also surprised that, in spite of eating regularly, his weight was declining and his work pants were now too large for him. Upon physical examination, his physician noted his inguinal lymph nodes were swollen although Max said they were not sore. Subsequent laboratory tests confirmed follicular, non-Hodgkin lymphoma. Chemotherapy in conjunction with rituximab was immediately initiated.

What are the key cellular differences between non-Hodgkin lymphoma and Hodgkin lymphoma?
The early manifestations of non-Hodgkin lymphoma and Hodgkin lymphoma in lymphatic tissue appear differently. In terms of lymphatic presentation, how would these two diseases appear clinically?
What are the pharmacologic properties of rituximab, and what is its mechanism of action on malignant cells?
Outline the structure of lymph node parenchyma including the areas where B and T lymphocytes reside. Where did Max’s lymphoma arise?

 

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What types of mutations could occur to genes and chromosomes? What type of autosomal dominant and autosomal recessive conditions could result?

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The idea that the placenta protects the embryo from harmful environmental substances was disproven between 1957-1961 when thousands of children were born with malformed limbs. Just as thalidamide, the causative agent of this malformation, affects a developing child, geneticists also attribute other adverse environmental factors (alcohol, malnutrition, exposures to various occupational hazards) as causative agents of genetic and chromosomal mutations. Consider adverse environmental factors. How would these factors affect the genetic precursors, the gametes, to fertilization? What types of mutations could occur to genes and chromosomes? What type of autosomal dominant and autosomal recessive conditions could result?

 

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What is the physiological basis that would explain why Henry’s anemia would cause him to have the symptoms he is experiencing?

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Henry is 77 years old and lives with his daughter and son-in-law. He has chronic renal failure, but likes to get out whenever he can to work in his daughter’s backyard garden. Over the last few months, he began to go outside less often. He said he was feeling unusually tired and he was running out of breath doing the simplest of tasks. He also said his head ached and he often felt dizzy. His daughter took him to his doctor who performed a complete physical examination and diagnosed Henry with anemia.

From what you know of Henry’s history, what type of anemia do you suspect he has? How would Henry’s red blood cells appear on a peripheral blood smear?
What is the physiological basis that would explain why Henry’s anemia would cause him to have the symptoms he is experiencing?
Predict the cellular adaptations erythrocytes undergo when chronic hypoxia is present. How would this be evident on an oxygen–hemoglobin dissociation curve?

 

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Describe the unhealthiest meal that you have created from the fast food restaurant using the nutritional value of menu items.

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. Describe the healthy meal that you have created from the fast food restaurant using the nutritional value of menu items.
a. Name the restaurant and then, write a nutritional analysis of the meal you have created (explain all of the nutrients found in the meal like carbs, protein, fat, and some essential vitamins and minerals)
b. Discuss your reaction to the analysis-Make sure to explain why you feel the way you do about this meal. For example, if your meal is composed primarily of fat, discuss that point; if you meal supplies a lot of sugar per serving, discuss that as well. Please also remember to link excess or limited amounts of nutrients with diseases or the potential for disease (too much fat may put you at risk for heart disease, not enough calcium may not support bone health, etc. Please make sure this section is as detailed as possible.
c. How will this information affect your future food choices? Make sure to explain why/why not you will eat this meal again and support your answer with the information found in the above sections.

2. Describe the unhealthiest meal that you have created from the fast food restaurant using the nutritional value of menu items.
a. Name the restaurant and then, write a nutritional analysis of the meal you have created (explain all of the nutrients found in the meal like carbs, protein, fat, and some essential vitamins and minerals)
b. Discuss your reaction to the analysis Make sure to explain why you feel the way you do about this meal. For example, if your meal is composed primarily of fat, discuss that point; if you meal supplies a lot of sugar per serving, discuss that as well. Please also remember to link excess or limited amounts of nutrients with diseases or the potential for disease (too much fat may put you at risk for heart disease, not enough calcium may not support bone health, etc. Please make sure this section is as detailed as possible.
c. How will this information affect your future food choices? Make sure to explain why/why not you will eat this meal again and support your answer with the information found in the above sections.

 

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