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Investigate the feasibility of a controlled-release acamprosate formulation and design an appropriate delivery system.

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Background: Acamprosate is a generic drug used in the treatment of alcohol dependence. It is taken long-term (up to 12 months) after alcohol cessation to maintain abstinence. The poor oral bioavailability (~10%) and rapid elimination from the blood stream (half-life ~3 h) requires that acamprosate be administered orally at a relatively high dose (1.3 g/day) […]

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