t is the half-life of a drug that has a volume of distribution at steady state equal to 462 liters and a clearance rate of 40 ml/min?
What is the half-life of a drug that has a volume of distribution at steady state equal to 462 liters and a clearance rate of 40 ml/min?
| A. | 2 hours |
| B. | 4 hours |
| C. | 8 hours |
| D. | 16 hours |
A drug has a volume of distribution of 300 Liters. What can we infer from this observation?
| A. | The drug is confined largely in the plasma |
| B. | The drug is subject to extensive first-pass metabolism |
| C. | The drug is distributed mainly in body tissues |
| D. | None of the above |
Of the following statements, which of the following is true for a drug that follows first-order elimination kinetics?
| A. | The amount eliminated per unit time is constant |
| B. | Elimination is proportional to the drug concentration in the plasma |
| C. | Elimination involves a rate-limiting enzymatic reaction that is saturated |
| D. | The rate of elimination is proportional to the plasma concentration |
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