Wheeler and Mathews (J. Biol. Chem. 287:3121831222 (2012)) reported the NAD+and NADH concentrations in yeast mitochondria as 21 mM and 0.4 mM, respectively. Consider the malate dehydrogenase reaction, which is part of the citric acid cycle: malate+NAD + ⟶oxaloacetate+NADH+H + ΔG ∘′ =+29.7kJ/mol Part A If malate concentration in yeast mitochondria is 0.1 mM, what is the maximum concentration of oxaloacetate needed to make the reaction exergonic at pH 7.0 and 37 ∘C? Chem. 287:3121831222 (2012)) reported the NAD+and NADH concentrations in yeast mitochondria as 21 mM and 0.4 mM, respectively. Consider the malate dehydrogenase reaction, which is part of the citric acid cycle: malate+NAD + ⟶oxaloacetate+NADH+H + ΔG ∘′ =+29.7kJ/mol Part A If malate concentration in yeast mitochondria is 0.1 mM, what is the maximum concentration of oxaloacetate needed to make the reaction exergonic at pH 7.0 and 37 ∘C?
Wheeler and Mathews (J. Biol. Chem. 287:3121831222 (2012)) reported the NAD+and NADH concentrations in
yeast mitochondria as 21 mM and 0.4 mM, respectively. Consider the malate dehydrogenase reaction, which is part of the citric acid cycle:
malate+NAD
+
⟶oxaloacetate+NADH+H
+
ΔG
∘′
=+29.7kJ/mol
Part A
If malate concentration in yeast mitochondria is 0.1 mM, what is the maximum concentration of oxaloacetate needed to make the reaction exergonic at pH 7.0 and 37 ∘C?
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