A 58-year-old male presents to the emergency department complaining of severe pain in his right big toe. The pain

began suddenly this evening after “having a few beers with the guys” He has never felt such excruciating pain and demands immediate relief. Physical examination reveals a temperture of 99.1 F and warm erythematous and tender fist metatarsophalangeal joint. Aspiration of the affected joint reveals numerous neutrophils and negatively birefringent, needle-shaped crystals. The physical terats the patient with colchicine, producing a dramatic resolution of symptoms. What is the mechanism of action of this drug?

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