A rare human disease – Snyder Robinson Syndrome– is due to a genetic defect inenzyme called SMS.
1) A rare human disease – Snyder Robinson Syndrome– is due to a genetic defect inenzyme called SMS. In a certain, isolated population, a heterozygote child carrying onemutant (defective) allele and one wild-type allele of SMS gene has 5% less chance ofsurviving into an reproductive adult compared to a homozygous child with two wild-typealleles. A homozygote child with two mutant alleles suffers 28% decline in survival relativeto a wild-type homozygote. (Once becoming adults, individuals with three genotypes allleave the same number of offspring, on average.) A deleterious mutation that destroys thenormal function of SMS occurs during meiosis with probability 10-4.(10 points total; 5 pts.ea).a. What is the expected long-term equilibrium frequency of the defective SMS allele inthis population?b. Given the answer to the above question, what is the expected number of children whoare homozygous for defective alleles if there are 10 million children in this population?2) A certain plant population has maintained the Hardy-Weinberg equilibrium. The currentfrequencies of allelesAandaare 0.7 and 0.3. If these plants suddenly stop outcrossing andstart reproducing by self-fertilization, what will be the frequencies of each genotype in thenext generation?(9 points; 3 ea. genotype freq.)
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