Reflective paper: PURPOSE: Reflect on learning and professional growth. DIRECTIONS: Write a one to two page reflective paper using APA style. Reflect on and explain how your participation in this course contributed to your achievement of the freshman level program outcome for leadership/interdisciplinary teamwork (Please see the leadership/interdisciplinary freshmen level outcome below: LEADERSHIP / INTERDISCIPLINARY TEAMWORK      Freshman Sophomore Junior Senior/BS Outcome   Develop beginning leadership skills for the delivery of safe and effective care. Prioritize the delivery of safe and effective care for patients with various levels of healthcare needs. Demonstrate beginning leadership skills as a team member in the delivery of safe and effective patient care. Collaborate with the interdisciplinary team in the delivery of patient-centered care in complex healthcare environments.     The goal for this paper will be for you to develop beginning leadership skills for the delivery of safe and effective care. Please respond to the questions below when writing your reflective paper: • What does this level outcome for leadership/interdisciplinary teamwork mean? • What knowledge or skills did you gain from this course and how does that knowledge/skill relate to the level outcome? • What assignments, activities, or experiences helped you achieve the level outcome? • What type of leadership style did you observe in your clinical settings? • What type of leadership style do feel is ideal for nursing environments? This assignment is pass or fail. Please see the rubric below for guidance as you write your paper. You must complete the assignment in order to pass the course. DUE DATE: April 30, 2016  Reflection Essay Rubric  Criteria  Expectation  Satisfactory or Unsatisfactory   Comments  Reflects on personal and professional growth. • Explains how the course has shaped personal knowledge, skills, and/or attitudes, especially those related to nursing. Correlates course activities with the level objective. • Identifies specific learning experiences, activities, and/or assignments from the course that relate to the level objective. • Explains how these experiences, activities, and/or assignments relate to the level objective.   Demonstrates achievement of the level objective. • Explains how personal knowledge, skills, and/or attitudes developed through the course demonstrate that he or she has achieved the level objective. • Provides examples of individual performance(s) in the course which validate that he or she exhibits the behaviors defined in the level objective.  Presentation  •

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Competency 208.5.4: Enzymology and Catalytic Mechanism – The graduate constructs models of enzymes, demonstrates how enzymes act as a catalyst in a reaction and factors that influence this reaction, and solves enzyme and catalysis problems.

Competency 208.5.5: Carbohydrate Metabolism, Adenosine Triphosphate (ATP) – The graduate constructs models of carbohydrates and demonstrates metabolism of carbohydrates; demonstrates how adenosine triphosphate (ATP) is essential to energy transfer in the cell and how irregularities in ATP synthesis in the cell can cause cytopathologies.

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Task 4: Metabolism

Introduction:

More and more researchers are discovering that many diseases are caused by biochemical deficiencies or defects. That is, instead of indicating that a disease is caused by a nutritional deficiency, researchers recognize that an underlying cause may be a single molecular structure within a cell that fails to turn a cellular process on or off. This is particularly true regarding metabolism. For this task, you will consider the biochemical implications in a metabolic disorder involving a normal component of food—fructose.

You should compile your work for this task in a single document (e.g., Microsoft Word, Google Document) that includes diagrams, text explanations, and references. If a requirement asks for an explanation, you should provide a written response in a narrative style (i.e., complete sentences rather than bullet points).

Note: Multimedia presentations (e.g., PowerPoint, Keynote) will not be accepted due to potential originality concerns.

Note: Please save submission documents as *.doc, *.docx, *.rtf, or *.pdf files. If you are using Google Documents, you must save the file in *.pdf format and upload the *.pdf file.

Requirements:

Demonstrate your understanding of the biochemical basis of hereditary fructose intolerance (HFI) by doing the following:
Describe two important features that make all enzymes catalysts.
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Explain the reactions catalyzed by enzymes in the first two steps of fructose metabolism in the liver, including each of the following:
the substrates acted on
the enzyme catalysts
the products generated
Discuss how a deficiency in aldolase B is responsible for HFI by doing the following:
Explain how the amount of the substrate of aldolase B is impacted by the deficiency.
Explain the role of the substrate in producing one condition of HFI (e.g., hypoglycemia, liver failure).

Explore how mitochondrial disease can occur at multiple levels in different mitochondrial processes by doing the following:
Explain what would hypothetically happen to the amount of ATP available to a cell if the entire Cori cycle were to occur and remain within a single cell (e.g., a muscle cell).
Identify specific numbers of ATP generated and used in the different parts of the cycle, in conjunction with your response from part B1.
Explain where in the CAC a hypothetical defect of an enzyme could occur that would decrease the overall ATP production of the mitochondria, including each of the following:
whether the entire cycle will continue to function
what will happen to the cycle products
why ATP production decreases

Note: This is a hypothetical defect, so the explanation should not include descriptions of any known disease.

Explain how a proton gradient is formed and used to make ATP during aerobic metabolism.

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