Question

Extensively research and comprehensive essay on the following

questions;

1. Describe the metabolic fates of phenylalanine; highlighting the synthesis and degradation pathways of catecholamines (dopamine, norepinephrine and epinephrine), melanin and thyroid hormones.

2. Describe the biochemical relationships between these disease and phenylalanine metabolism; albinism, phyenylketonuria, parkinson’s disease and Haloperidol toxicity.

3. Describe the pharmacological importance of the enzymes COMT and MAO.

4. How can a knowledge of phenylalanine metabolism be useful in the laboratory diagnosis of pheochromocytoma?

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