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In mice a reduction in the expression of the Sortin Nexin 27, (SNX27) gene results in synaptic dysfunction in the brain. The expression of human SNX27 (cytogenetic location: 1q21) is reduced in Down syndrome patients although there is no mutation in the SNX27 gene, and this reduction may be a cause of some of the mental defects in Down syndrome patients (Wang etal. 2013, Nature Medicine 19, 473-480). One hypothesis is that this reduction in SNX27 in Down syndrome patients is caused by an increase in the amount of the negative regulatory RNAi molecule miR-155, (cytogenetic location: 21q21.3). You have been asked to determine whether miR-155 is increased in Down syndrome patients.

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In mice a reduction in the expression of the Sortin Nexin 27, (SNX27) gene results in synaptic dysfunction in the brain. The expression of human SNX27 (cytogenetic location: 1q21) is reduced in Down syndrome patients although there is no mutation in the SNX27 gene, and this reduction may be a cause of some of the mental defects in Down syndrome patients (Wang etal. 2013, Nature Medicine 19, 473-480). One hypothesis is that this reduction in SNX27 in Down syndrome patients is caused by an increase in the amount of the negative regulatory RNAi molecule miR-155, (cytogenetic location: 21q21.3). You have been asked to determine whether miR-155 is increased in Down syndrome patients.

a. Describe what test or tests you would do, and how you would do them.

b. What results would you would expect if this hypothesis about miR-155 is correct?

c. Briefly explain why you think your results support the hypothesis.

The post In mice a reduction in the expression of the Sortin Nexin 27, (SNX27) gene results in synaptic dysfunction in the brain. The expression of human SNX27 (cytogenetic location: 1q21) is reduced in Down syndrome patients although there is no mutation in the SNX27 gene, and this reduction may be a cause of some of the mental defects in Down syndrome patients (Wang etal. 2013, Nature Medicine 19, 473-480). One hypothesis is that this reduction in SNX27 in Down syndrome patients is caused by an increase in the amount of the negative regulatory RNAi molecule miR-155, (cytogenetic location: 21q21.3). You have been asked to determine whether miR-155 is increased in Down syndrome patients. appeared first on Academicheroes.com.

 
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