12 Which of the following symptom clusters is most likely in a 16-year-old male with major depressive disorder?

A. Disturbance of mood, loss of interest, and mood-congruent hallucinations

B. Irritability, persistent abdominal complaints, and insomnia

C. Decreased concentration, social withdrawal, and substance abuse

D. Pervasive anhedonia, hopelessness, and severe psychomotor retardation