Which of the following alternatives would be suitable to consider in a study using swine?

Which of the following alternatives would be suitable to consider in a study using swine?

Replacing swine with an animal known to be a superior model for the problem being studied
Increasing the sample size to compensate for losses associated with personnel inexperienced in the procedure
Substituting an animal model that is less expensive than swine
Avoiding use of an analgesic after a surgical procedure to minimize experimental variability
Substituting sheep for pigs as the proposed animal model because they are a less sentient species

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