Which of the statements concerning blood collection in mice and rats is true?

Which of the statements concerning blood collection in mice and rats is true?
A) Retroorbital bleeding should be performed on conscious animals to maintain adequate blood pressure.
B) Retroorbital bleeding should be performed on conscious animals to maintain adequate blood pressure.
C) Less painful alternatives to retroorbital blood collection include lateral saphenous, facial (submandibular) and jugular vein blood collection.
D) No more than about 10% of the body weight should be removed as blood at one time.

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